Central data hub to speed progress on early psychosis and high‑risk symptoms
Clinical Trial Data Processing, Analysis, and Coordination Center (CT-DPACC) for Accelerating Medicines Partnership Schizophrenia (AMP SCZ) Project
This effort brings together and standardizes data from young people with early or high‑risk psychosis so researchers can find better tests and treatments for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11375385 on NIH RePORTER |
What this research studies
From your perspective, this project acts like a central data team that collects and organizes information from many clinics caring for young people with early psychosis or warning signs. The team harmonizes clinical records, brain scans, cognitive tests, and other biological measurements so patterns can be studied across large groups. They run analyses, validate potential biomarkers, and coordinate how future clinical trials are designed and reported. By making data consistent and broadly available to researchers, the goal is to speed up development of clearer tests and more targeted therapies.
Who could benefit from this research
Good fit: Young people experiencing a first episode of psychosis or showing recent attenuated psychotic symptoms (clinical high risk) are the most relevant candidates for related studies.
Not a fit: People without psychotic symptoms or those with long‑standing, stable psychiatric conditions unrelated to early psychosis are unlikely to see direct benefits from this coordination effort in the near term.
Why it matters
Potential benefit: If successful, this work could identify reliable brain or cognitive markers that help target treatments earlier and improve chances of preventing or reducing psychosis and related decline.
How similar studies have performed: Past clinical trials trying to prevent psychosis have mostly not succeeded, but larger collaborative projects that standardize data and validate biomarkers are a newer approach showing promise in improving research quality.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Shenton, Martha E. — Brigham and Women's Hospital
- Study coordinator: Shenton, Martha E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.