Central data and coordination center to improve care for early psychosis and high-risk youth
Clinical Trial Data Processing, Analysis, and Coordination Center (CT-DPACC) for Accelerating Medicines Partnership Schizophrenia (AMP SCZ) Project
['FUNDING_OTHER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11118972
This project organizes and analyzes health and brain data from young people with early psychosis or who are at high risk, to help find better tests and treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11118972 on ClinicalTrials.gov |
What this research studies
The center gathers and standardizes clinical, brain imaging, and biological data from people with a first episode of psychosis or attenuated psychotic symptoms across many sites. It applies big-data tools and shared protocols so researchers can combine large numbers of participants and look for reliable biomarkers linked to outcomes. The team manages data quality, analysis pipelines, and coordination between clinics to speed up future studies and testing of new treatments. By making data consistent and accessible, the center aims to identify subgroups who might respond to specific interventions.
Who could benefit from this research
Good fit: Young people with a recent first episode of psychosis or with attenuated/clinical high-risk psychotic symptoms are the most relevant participants.
Not a fit: People without psychotic symptoms or those not seen at participating AMP SCZ sites are unlikely to receive direct benefits from this coordination center.
Why it matters
Potential benefit: If successful, this work could lead to tests that predict who will develop psychosis and enable faster, more targeted treatments.
How similar studies have performed: Past smaller trials largely failed to prevent psychosis, so this large, harmonized data approach is relatively new and designed to overcome those limitations.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHENTON, MARTHA E. — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: SHENTON, MARTHA E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.