Central coordination for improving understanding of ABO blood group immunity
Core A - Administration core
This program organizes collection and sharing of patient blood samples and data to improve how we understand immune reactions to ABO blood types for people facing transfusions or transplants.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11135371 on NIH RePORTER |
What this research studies
From a patient viewpoint, this administrative core brings together multiple research teams so they can work as one program on ABO blood group immunity and incompatibility. It manages collection and storage of human blood samples, oversees a central biobank, and coordinates data sharing and quality control. The core also links with a biostatistics team for unified data analysis and ensures consistent procedures and human-subject protections across projects. By coordinating resources and expertise, it enables studies of antibody formation, antigen structure, and the role of microbes in shaping blood-group antibodies.
Who could benefit from this research
Good fit: Ideal candidates are people who have had or may need blood transfusions or organ transplants, or those with known antibodies to ABO blood groups who can provide blood samples.
Not a fit: People without transfusion or transplant needs and those unwilling to provide samples are unlikely to receive direct benefits from this administrative core.
Why it matters
Potential benefit: If successful, this could lead to better ways to prevent and manage ABO incompatibility in transfusions and transplants.
How similar studies have performed: Prior research has characterized some immune responses to blood group antigens, but this integrated program approach to centralizing samples, data, and analysis is relatively novel.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Stowell, Sean R — Brigham and Women's Hospital
- Study coordinator: Stowell, Sean R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.