Center to understand and treat eczema (atopic dermatitis)
ATOPIC DERMATITIS RESEARCH NETWORK (ADRN) CLINICAL RESEARCH CENTER
This project looks at biological differences in people with different types of atopic dermatitis, including those prone to eczema herpeticum and those with food allergy, to help improve care for children and adults.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project ID | NIH-11310152 on NIH RePORTER |
What this research studies
This project is building a clinical and laboratory center that will recruit children and adults with atopic dermatitis (eczema) to take part in coordinated studies. Participants will provide clinical information, skin biopsies, and other samples so researchers can grow skin cells and analyze genes, lipids, RNA, and proteins. The team will compare people who develop eczema herpeticum, those who do not, and those with food allergies to define biological endotypes that explain differences in disease. Those findings are intended to guide better prevention of viral complications and more personalized treatments.
Who could benefit from this research
Good fit: Adults and children with atopic dermatitis, especially those with a history of eczema herpeticum or with food allergies, are ideal candidates.
Not a fit: People without atopic dermatitis or whose skin problems stem from non-atopic causes are unlikely to benefit directly from this project.
Why it matters
Potential benefit: Could identify markers that predict who is at higher risk for severe skin infections and help match patients with more targeted treatments.
How similar studies have performed: Earlier research has identified some biomarkers and endotypes in eczema, but combining genomics, lipidomics, transcriptomics, and proteomics across pediatric and adult patients is a relatively new and promising approach.
Where this research is happening
Denver, United States
- National Jewish Health — Denver, United States (Active)
Researchers
- Principal investigator: Leung, Donald Ym — National Jewish Health
- Study coordinator: Leung, Donald Ym
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.