Center to understand and treat eczema (atopic dermatitis)
Official title: ATOPIC DERMATITIS RESEARCH NETWORK (ADRN) CLINICAL RESEARCH CENTER
Funded at National Jewish Health · NIH-11310152 · Data updated 2026-11-12
This project looks at biological differences in people with different types of atopic dermatitis, including those prone to eczema herpeticum and those with food allergy, to help improve care for children and adults.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Jewish Health NIH-funded |
| Lab location | 1 site (Denver, United States) |
| Project start | April 10, 2020 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $330,358 |
| NIH project number | 5U01AI152037-07 |
| Project ID | NIH-11310152 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults and children with atopic dermatitis, especially those with a history of eczema herpeticum or with food allergies, are ideal candidates.
✕Less likely to help
People without atopic dermatitis or whose skin problems stem from non-atopic causes are unlikely to benefit directly from this project.
What this research studies
This project is building a clinical and laboratory center that will recruit children and adults with atopic dermatitis (eczema) to take part in coordinated studies. Participants will provide clinical information, skin biopsies, and other samples so researchers can grow skin cells and analyze genes, lipids, RNA, and proteins. The team will compare people who develop eczema herpeticum, those who do not, and those with food allergies to define biological endotypes that explain differences in disease. Those findings are intended to guide better prevention of viral complications and more personalized treatments.
Why it matters
Potential benefit: Could identify markers that predict who is at higher risk for severe skin infections and help match patients with more targeted treatments.
How similar studies have gone: Earlier research has identified some biomarkers and endotypes in eczema, but combining genomics, lipidomics, transcriptomics, and proteomics across pediatric and adult patients is a relatively new and promising approach.
Where this research is happening
-
National Jewish Health
Denver, United States Active
Researchers
- Principal investigator: Leung, Donald Ym — National Jewish Health
- Study coordinator: Leung, Donald Ym
Related research
Other NIH-funded projects on the same topics.
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Stopping Atopic Dermatitis and Allergy: Preventing Food Allergy by Protecting the Skin
A large study in infants at high risk for allergies tests whether using a skin barrier cream together with early, proactive skin care can prevent peanut allergy and other food allergies.
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SEAL Study: Preventing peanut allergy by protecting baby skin
This trial tests whether using a skin-emollient and proactive skin steroids early in life can prevent peanut allergy in high-risk infants.
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SEAL Study: Prevent allergy by protecting the baby’s skin
A very young group of high-risk babies will try a early skin-care plan to reduce eczema and prevent peanut allergy.
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Understanding how skin fungi affect atopic dermatitis in adults
A study will look at how the skin's fungal community influences atopic dermatitis in adults and whether this understanding could lead to new treatments.
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Preventing eczema-related allergies by strengthening infants' skin barrier
This project will see if using a trilipid skin cream plus proactive mild topical steroids in infants with early dry skin or eczema lowers their chances of developing food allergies.
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Personalized predictions for how atopic dermatitis may progress in kids and teens
A patient-friendly plan to forecast how early-onset eczema might evolve in children and young people using simple health clues and data from diverse settings.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.