Center coordinating genetics-driven drug discovery for healthier aging
Administrative Core
This program uses genes from very long-lived people to find drug targets that might help older adults stay healthier as they age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-11161512 on NIH RePORTER |
What this research studies
You would be contributing to work that studies DNA from centenarians and other older adults to find gene changes linked to long, healthy lives. The team will expand whole-exome sequencing, test gene functions in lab models, and develop mouse models to see which pathways can be targeted with drugs. Researchers will build a pipeline of candidate interventions to move the most promising options toward testing. The project is coordinated across institutions and includes recruiting and detailed health phenotyping of older participants.
Who could benefit from this research
Good fit: Ideal participants are older adults, including exceptionally long-lived individuals or volunteers willing to provide genetic samples and undergo health tests and phenotyping.
Not a fit: Younger people or those seeking an immediate treatment are unlikely to get direct short-term benefit from this long-term discovery program.
Why it matters
Potential benefit: If successful, this work could identify drugs or targets that extend healthspan and reduce multiple age-related diseases for older adults.
How similar studies have performed: Related geroscience studies have found promising aging pathways and produced effective interventions in animals, but direct, proven human treatments remain limited.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Vijg, Jan — Albert Einstein College of Medicine
- Study coordinator: Vijg, Jan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.