Cell energy and its role in lymphatic vessel health
Mitochondrial respiration as a regulator of lymphatic cell fate and therapeutic lymphangiogenesis
['FUNDING_R01'] · NORTHWESTERN UNIVERSITY · NIH-11166489
This project explores how the energy-making parts of our cells, called mitochondria, guide the development and growth of lymphatic vessels, hoping to find new ways to support lymphatic health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTHWESTERN UNIVERSITY (nih funded) |
| Locations | 1 site (CHICAGO, UNITED STATES) |
| Trial ID | NIH-11166489 on ClinicalTrials.gov |
What this research studies
This project aims to understand how the energy-producing parts of our cells, called mitochondria, control the development and growth of lymphatic vessels. Lymphatic vessels are crucial for fluid balance and immune function, and their proper formation is vital for health. Researchers believe that how these cells use energy is key to their function and growth, especially in conditions where new lymphatic vessels are needed or where existing ones are not working correctly. This work uses mouse models of heart injury and pancreatitis to see if controlling this energy process can help improve lymphatic vessel growth and function.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients at this stage, but future clinical applications might benefit individuals with lymphatic system disorders, heart injury, or pancreatitis.
Not a fit: Patients not experiencing conditions related to lymphatic vessel dysfunction, heart injury, or pancreatitis would likely not benefit from the future applications of this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that encourage the growth of healthy lymphatic vessels, potentially helping patients with conditions like heart injury or pancreatitis.
How similar studies have performed: While the role of metabolism in blood vessel growth is known, this specific focus on mitochondrial respiration in lymphatic cells and its therapeutic potential is a newer area of exploration.
Where this research is happening
CHICAGO, UNITED STATES
- NORTHWESTERN UNIVERSITY — CHICAGO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: OLIVER, GUILLERMO C — NORTHWESTERN UNIVERSITY
- Study coordinator: OLIVER, GUILLERMO C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.