Cell-derived vesicles to slow diabetes-related kidney aging
Extracellular vesicle-based senotherapeutics for aging diabetic kidneydisease
['FUNDING_R01'] · MAYO CLINIC JACKSONVILLE · NIH-11307651
Using tiny particles released by therapeutic cells to reduce inflammation and cellular aging that damage kidneys in people with diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-11307651 on ClinicalTrials.gov |
What this research studies
Researchers plan to develop therapies made from extracellular vesicles (tiny packages) produced by mesenchymal stromal cells that carry protective microRNAs. They will test how these vesicles affect inflammation, immune cell infiltration, and senescent (aged) cells in models of diabetes-related kidney disease and aging. The team will measure effects on kidney structure and function and refine delivery approaches. The goal is to create senotherapeutics that could eventually be given to people to slow age-related kidney decline from diabetes.
Who could benefit from this research
Good fit: Adults with diabetes who are at risk for or have early-stage diabetic kidney disease and age-related kidney decline would be the most relevant candidates.
Not a fit: People with non-diabetic causes of kidney failure or those with advanced end-stage kidney disease are less likely to benefit from this therapy.
Why it matters
Potential benefit: If successful, this approach could slow or prevent diabetes-related kidney aging and help preserve kidney function, possibly delaying dialysis or transplant.
How similar studies have performed: Related cell-derived vesicle therapies have shown promising reductions in inflammation and senescence in animal studies, but human testing remains limited.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HICKSON, LATONYA J — MAYO CLINIC JACKSONVILLE
- Study coordinator: HICKSON, LATONYA J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.