Cell complex that helps build proteins
The mammalian multi-tRNA synthetase complex
['FUNDING_R01'] · CLEVELAND CLINIC LERNER COM-CWRU · NIH-11251767
Learning how a protein-making cell complex works because changes in its parts can cause brain disorders in children.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CLEVELAND CLINIC LERNER COM-CWRU (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11251767 on ClinicalTrials.gov |
What this research studies
Scientists will map the structure and connections of the multi-tRNA synthetase complex, a group of proteins that helps build other proteins in cells. They will use advanced lab methods like cross-linking mass spectrometry and computer molecular modeling to create a detailed 3-D map of how the pieces fit together. The team focuses on proteins whose gene mutations are linked to pediatric brain disorders such as hypomyelinating leukodystrophy and progressive microcephaly. The goal is to show how those genetic changes damage brain cells and to inform future diagnostic or therapeutic work.
Who could benefit from this research
Good fit: Children (or their families) with genetic diagnoses of hypomyelinating leukodystrophy, progressive microcephaly, or mutations in aminoacyl-tRNA synthetase genes would be most relevant to this research.
Not a fit: People without those specific genetic mutations or with unrelated conditions are unlikely to benefit directly from this basic lab-focused project.
Why it matters
Potential benefit: If successful, this work could reveal how certain genetic mutations cause pediatric brain disorders and point to targets for new diagnostics or treatments.
How similar studies have performed: Previous genetic studies have linked these proteins to disease and initial structural models exist, but the detailed cross-linking and 3-D mapping approach is relatively new for this complex.
Where this research is happening
CLEVELAND, UNITED STATES
- CLEVELAND CLINIC LERNER COM-CWRU — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FOX, PAUL L — CLEVELAND CLINIC LERNER COM-CWRU
- Study coordinator: FOX, PAUL L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.