Cell changes in Dementia with Lewy bodies
Single-Nuclei Multiomic Analysis of DLB Progression
Researchers are using advanced cell-level tests on donated brain tissue to map how different brain cells change as Dementia with Lewy bodies gets worse.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10699946 on NIH RePORTER |
What this research studies
If you or a loved one donates brain tissue after death, the team will profile individual cell nuclei to measure both gene activity and chromatin accessibility from the same cells. They will sample multiple brain regions and many cell types (neurons, microglia, astrocytes, oligodendrocytes, endothelial cells, and immune cells) to see how patterns change across disease stages. The group will apply a new "correlated pseudo-pathogenesis" trajectory and gene-peak linking to order cells along progression and connect gene expression to regulatory DNA changes. The goal is a detailed, cell-by-cell map of DLB progression that can point to specific cells and pathways involved in the disease.
Who could benefit from this research
Good fit: Ideal candidates are people diagnosed with Dementia with Lewy bodies or related dementias who are willing to consent to brain donation or whose families can coordinate postmortem tissue donation.
Not a fit: People looking for immediate treatment options or those not willing or able to participate in brain donation are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: This work could reveal specific cell types and molecular changes that become targets for future diagnostics or treatments for Dementia with Lewy bodies.
How similar studies have performed: Single-nucleus and multiomic approaches have provided useful cell-specific insights in Alzheimer’s and Parkinson’s research, though applying combined ATAC+RNA profiling across DLB progression is relatively new.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Kim, Yoon-Seong — Rutgers Biomedical and Health Sciences
- Study coordinator: Kim, Yoon-Seong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.