CD8 T cells and their role in driving inflammation in arthritis
CD8 T cell derived Granzyme K activates complement that drives synovial fibroblast inflammation
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10933485
This study is looking at how certain immune cells called CD8 T cells can cause inflammation in rheumatoid arthritis by using a protein called Granzyme K, and it hopes to find new ways to help people with RA understand their condition better and explore new treatment options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10933485 on ClinicalTrials.gov |
What this research studies
This research investigates how CD8 T cells contribute to inflammation in rheumatoid arthritis (RA) by activating a complement pathway through a protein called Granzyme K. The study aims to understand the mechanisms by which Granzyme K influences synovial fibroblasts, which are cells involved in joint inflammation. By examining the interactions between CD8 T cells and these fibroblasts, the research seeks to uncover new insights into the inflammatory processes in RA. Patients may benefit from a better understanding of their condition and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis, particularly those exhibiting elevated CD8 T cell activity.
Not a fit: Patients with rheumatoid arthritis who do not have significant CD8 T cell involvement may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the inflammatory processes in rheumatoid arthritis.
How similar studies have performed: Other research has shown that targeting complement activation can influence inflammatory responses, suggesting potential for success in this novel approach.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BRENNER, MICHAEL B. — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: BRENNER, MICHAEL B.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.