Causes of NF1-related Schwann cell (nerve) tumors
Identification of Novel Pathways Causing NF1-Driven Schwann Cell Tumors
This project looks for the proteins and pathways that make nerve tumors grow in people with neurofibromatosis type 1 and tests a targeted therapy in lab and animal models.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11247042 on NIH RePORTER |
What this research studies
We want to find which proteins that interact with neurofibromin cause Schwann cells to form neurofibromas in NF1. Researchers will use human Schwann cells in the lab, genetically altered mice, and modern biochemical and molecular techniques to identify which RAS family proteins and binding partners drive tumor growth. They will then test whether blocking those pathways can slow or shrink tumors in mouse models. This work aims to point toward drug targets that could lead to new treatments for people with NF1.
Who could benefit from this research
Good fit: People with neurofibromatosis type 1 who have peripheral nerve tumors (neurofibromas) would be the most likely candidates for future therapies arising from this work.
Not a fit: People without NF1 or those whose tumors are not Schwann cell–derived are unlikely to benefit from this specific line of research.
Why it matters
Potential benefit: Could point to new drug targets that slow or shrink neurofibromas in people with NF1.
How similar studies have performed: Previous preclinical studies targeting RAS and related pathways have slowed NF1-related tumor growth in models, but turning those findings into effective human treatments has been difficult.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Ratner, Nancy — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Ratner, Nancy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.