Cataloging somatic mutations in human tissues
Official title: Whole Individual Comprehensive KnowlEDge: Somatic Mosaicism across Human Tissues (WICKed SMaHT)
Funded at Broad Institute, INC. · NIH-11088767 · Data updated 2026-11-12
This study is looking to gather information about changes in our cells that can happen in different parts of the body, especially as we age, to better understand how these changes might affect our health, and we’d love for patients to help by sharing tissue samples or information.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $3,080,661 |
| NIH project number | 5UM1DA058235-03 |
| Project ID | NIH-11088767 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include individuals with a history of age-related conditions or cancers, as well as healthy volunteers for comparative analysis.
✕Less likely to help
Patients with acute conditions unrelated to somatic mutations or those who are not willing to provide tissue samples may not benefit from this research.
What this research studies
This research aims to create a comprehensive dataset that catalogs somatic mutations across various human tissues. By analyzing the type and frequency of these mutations, as well as their locations within the body, the study seeks to understand how these changes affect cellular function and contribute to diseases, particularly those related to aging. The approach involves advanced genomic techniques to gather high-resolution data from multiple tissues, providing insights into the relationship between somatic mutations and health outcomes. Patients may be involved in providing tissue samples or data to help build this important resource.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of age-related diseases and cancers.
How similar studies have gone: Previous research has shown promising results in understanding somatic mutations in limited tissues, but this approach aims to expand that knowledge across a broader range of tissues.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Ardlie, Kristin — Broad Institute, INC.
- Study coordinator: Ardlie, Kristin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.