CASCADE Network to prevent cervical cancer in women with HIV
UNC CASCADE Network Research Base
This project will develop and roll out better ways to screen for and treat cervical precancer in women living with HIV to lower invasive cervical cancer risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11101389 on NIH RePORTER |
What this research studies
You would be invited into a network that designs and runs practical trials to improve cervical cancer prevention for women with HIV. The team will compare approaches to managing positive screens and optimize precancer treatment using tools like automated visual evaluation and pathology guidance. They will test how those approaches work in real clinics and measure costs so the best options can be scaled. Results aim to change how screening and treatment are delivered in both the US and low- and middle-income countries.
Who could benefit from this research
Good fit: Ideal candidates are women living with HIV who are eligible for cervical cancer screening or who have abnormal screening results and are at risk for cervical precancer.
Not a fit: People who are not living with HIV or those with already advanced invasive cervical cancer are unlikely to benefit directly from these prevention-focused efforts.
Why it matters
Potential benefit: If successful, this work could lower rates of invasive cervical cancer among women living with HIV by improving access to effective screening and treatment.
How similar studies have performed: Screen-and-treat programs and emerging automated visual evaluation methods have shown promise, but well-designed trials specifically for women living with HIV remain limited.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Smith, Jennifer Susan — Univ of North Carolina Chapel Hill
- Study coordinator: Smith, Jennifer Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.