Cancer bioinformatics, biostatistics, and genomics core
Core 2: Bioinformatics/Biostatistics/Genomics
['FUNDING_P01'] · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · NIH-11189772
This project builds a shared computational platform to help cancer researchers analyze tumor samples, patient-derived models, and related data.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11189772 on ClinicalTrials.gov |
What this research studies
From a patient's view, this core creates a single place where sequencing data, tumor samples, organoids, and other lab results are linked and analyzed together. The team will combine bioinformatics, biostatistics, genomics, and transcriptomics tools to find mutation patterns, clonal changes, and signaling pathways in tumors. They will look for how factors like metabolic stress and hypernutrition change tumor evolution and for cross-talk between biomarkers such as NRF2 and ATF6. The core also maintains the database and analysis pipelines used by the related projects so findings can be compared across samples and experiments.
Who could benefit from this research
Good fit: Ideal participants are people with cancer who can donate tumor tissue, blood, or who are enrolled in projects that generate organoids or patient-derived xenografts.
Not a fit: Patients without tumor samples, those with non-cancer conditions, or people not enrolled at the participating institutions are unlikely to take part or see direct benefits from this core.
Why it matters
Potential benefit: If successful, this work could speed discovery of new cancer biomarkers and potential treatment targets by revealing key mutation patterns and pathways.
How similar studies have performed: Combining genomics and computational analysis has already helped identify useful cancer biomarkers, though applying an integrated core to these specific pathway questions and datasets is relatively new.
Where this research is happening
LA JOLLA, UNITED STATES
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TAMAYO, PABLO — SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Study coordinator: TAMAYO, PABLO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Patient, Cancers