Calcium-Driven Fibroblast Changes in the Atria Leading to Fibrosis and Arrhythmia
Official title: Calcium Driven Fibroblast Dysregulation in Human Atrial Profibrotic Remodeling
Funded at University of California at Davis · NIH-11525980 · Data updated 2026-11-12
This project looks at how calcium balance inside heart cells and their supporting fibroblasts may drive scar formation in the atria, which can promote atrial fibrillation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $199,405 |
| NIH project number | 3R01HL176651-02S1 |
| Project ID | NIH-11525980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with atrial fibrillation or at-risk individuals whose condition could be influenced by therapies targeting atrial fibrosis.
✕Less likely to help
Individuals without AF or atrial fibrosis or those not followed by structural remodeling strategies may not directly benefit.
What this research studies
Atrial fibrillation often worsens as the heart tissue becomes fibrotic, and this study is exploring how calcium transport in cells and fibroblasts contributes to that fibrotic change. By using human-relevant models, the research aims to map how calcium dysregulation influences atrial cell and fibroblast behavior that underlies structural remodeling. The team plans to connect laboratory findings to potential strategies that could slow or prevent progression of AF by targeting fibrosis.
Why it matters
Potential benefit: If successful, the work could identify new approaches to prevent or reduce atrial fibrosis and potentially limit AF progression.
How similar studies have gone: Previous studies link Ca2+ handling and fibroblast activity to fibrosis, but this project seeks more direct human-relevant mechanisms in atrial tissue.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Grandi, Eleonora — University of California at Davis
- Study coordinator: Grandi, Eleonora
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.