Calciprotein particles and blood vessel calcification in people with chronic kidney disease
Calciprotein Particles and Vascular Calcification in Patients with Chronic Kidney Disease
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11249988
This project explores how tiny mineral-protein particles in the blood may cause hardening and calcium buildup in the arteries of people with chronic kidney disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11249988 on ClinicalTrials.gov |
What this research studies
We will collect blood from people with chronic kidney disease to measure calciprotein particles (CPPs) and use their serum on human blood vessel cells in the lab. The team will study whether CPPs cause large (macro-) and tiny (micro-) calcium deposits and trigger inflammation or changes in endothelial and smooth muscle cells. Because vessel calcification resembles bone formation, researchers will also check whether blocking vascular calcification could harm bone health. The goal is to understand mechanisms so future treatments can target CPPs to protect blood vessels without weakening bones.
Who could benefit from this research
Good fit: Adults with chronic kidney disease, particularly those with signs of vascular calcification and who are willing to provide blood samples, would be ideal candidates.
Not a fit: People without chronic kidney disease or without evidence of vascular calcification, and those seeking immediate treatment, are unlikely to receive direct benefit from this mechanistic research.
Why it matters
Potential benefit: If successful, the findings could lead to new therapies that reduce artery calcification in CKD patients without damaging bone health.
How similar studies have performed: Preclinical lab and animal studies have shown CPPs can drive vascular calcification, but direct human-based evidence is limited, making this work relatively novel and important to confirm those findings.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, WEI — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: CHEN, WEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.