C1ORF150 control of human mast cell activation in urticaria
Official title: C1ORF150 Regulation of Human Mast Cell Activation
Funded at University of New Hampshire · NIH-11454839 · Data updated 2026-11-12
A study in people with chronic hives to understand how a specific gene variant (C1ORF150) affects mast cell activation and how this could lead to better treatments.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Hampshire NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $244,410 |
| NIH project number | 1R21AI193447-01A1 |
| Project ID | NIH-11454839 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic urticaria or those affected by symptoms that do not respond to standard therapies.
✕Less likely to help
Patients without CU or those not experiencing mast cell–driven symptoms may not benefit directly.
What this research studies
This project focuses on how a human gene variant called C1ORF150 affects mast cell activation that drives chronic urticaria. Researchers will compare the normal and altered forms of the C1ORF150 protein to see how they influence signaling in mast cells. The work uses cellular models and human relevance to test whether the full-length protein suppresses activation and whether the altered isoform disrupts this suppression. Findings could point to new ways to improve response to antihistamines or other therapies for people with CU.
Why it matters
Potential benefit: If successful, the research could identify new targets to reduce mast cell activation and improve treatment for people with chronic urticaria.
How similar studies have gone: Preliminary genetic associations and splice-variant studies suggest this approach could reveal meaningful mechanisms in CU.
Where this research is happening
-
University of New Hampshire
Durham, United States Active
Researchers
- Principal investigator: Wojchowski, Don Michael — University of New Hampshire
- Study coordinator: Wojchowski, Don Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.