Building a database to understand the clinical importance of cancer-related genetic changes
Creation of a knowledgebase of high quality assertions of the clinical actionability of somatic variants in cancer
This study is working to gather important information about genetic changes in cancer cells to help doctors better understand how these changes affect cancer diagnosis and treatment, making it easier for them to provide the best care for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10931317 on NIH RePORTER |
What this research studies
This research aims to create a comprehensive knowledgebase that evaluates the clinical significance of somatic variants, which are genetic changes occurring in cancer cells. By utilizing existing platforms and adapting established procedures, the project will gather and curate high-quality information on how these variants affect cancer diagnosis, prognosis, and treatment responses. The goal is to enhance the understanding of these genetic alterations, making it easier for healthcare providers to make informed decisions regarding patient care. This initiative will also promote collaboration among experts in the field to ensure the data is reliable and actionable.
Who could benefit from this research
Good fit: Ideal candidates for this research include cancer patients whose tumors have identifiable somatic variants that may impact their treatment options.
Not a fit: Patients with cancers that do not have known somatic variants or those whose treatment does not involve genetic considerations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve cancer treatment strategies by providing clearer insights into how specific genetic changes influence patient outcomes.
How similar studies have performed: Other research initiatives have successfully established similar databases for germline variants, indicating a promising potential for this approach in somatic variants.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Griffith, Malachi — Washington University
- Study coordinator: Griffith, Malachi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.