Building a data ecosystem for studying human gene expression and regulation
GTEx engagement with the CFDE-CC and other DCCs towards building a data ecosystem spanning the Common Fund projects
This study is looking at how our genes work in different parts of the body to help us understand why some people get certain diseases, and it’s designed to help researchers find new ways to improve health for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10129013 on NIH RePORTER |
What this research studies
This research focuses on enhancing the Genotype-Tissue Expression (GTEx) project, which aims to provide a comprehensive resource for understanding human gene expression and regulation across various tissues. By analyzing data from nearly 49,000 tissue samples collected from adult donors, the project seeks to uncover the genetic factors that influence disease susceptibility. The methodology includes advanced sequencing techniques and the integration of various molecular data types to create a rich dataset that can be utilized by the scientific community. Patients may benefit from insights gained regarding the genetic underpinnings of complex diseases.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include adults with a family history of complex diseases or those interested in genetic research.
Not a fit: Patients with no interest in genetic factors or those not affected by complex diseases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors in diseases, potentially guiding personalized treatment strategies.
How similar studies have performed: Previous studies utilizing similar genomic approaches have shown success in identifying genetic influences on health, indicating a promising avenue for this research.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Ardlie, Kristin — Broad Institute, INC.
- Study coordinator: Ardlie, Kristin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.