Bromocriptine to help heart recovery after pregnancy-related heart failure (REBIRTH)
(2/2) Randomized Evaluation of Bromocriptine In Myocardial Recovery THerapy for Peripartum Cardiomyopathy (REBIRTH)
['FUNDING_OTHER'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-11171580
This research compares standard heart failure care with and without the drug bromocriptine for women who develop peripartum cardiomyopathy to test whether adding bromocriptine helps the heart recover.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-11171580 on ClinicalTrials.gov |
What this research studies
If you have heart failure around the time of childbirth (peripartum cardiomyopathy), this project compares usual heart failure medicines alone versus the same care plus bromocriptine, a drug that lowers prolactin. You would be randomly assigned to one of the two groups and followed with clinic visits, heart imaging, and tests over the first year after delivery. The University of Pittsburgh will coordinate data across multiple sites in North America to enroll a racially diverse group of women. The goal is to learn whether adding bromocriptine helps more women regain heart function and avoid long-term heart problems.
Who could benefit from this research
Good fit: Women diagnosed with peripartum cardiomyopathy (heart failure occurring late in pregnancy or within months after delivery) who meet the study's medical criteria and can attend follow-up visits are the ideal candidates.
Not a fit: Women without peripartum cardiomyopathy, those whose heart function has already recovered, or those with medical contraindications to bromocriptine or who cannot stop breastfeeding may not benefit or be eligible.
Why it matters
Potential benefit: If successful, adding bromocriptine could increase the chance that women with peripartum cardiomyopathy recover heart function and reduce chronic heart failure and related deaths.
How similar studies have performed: Several smaller studies, mostly outside North America, have suggested benefit from bromocriptine in PPCM, but a large randomized trial in a multi-racial North American population is new.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABEBE, KALEAB Z — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: ABEBE, KALEAB Z
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.