Broad coronavirus vaccine to protect against many strains
The Development and Evaluation of Pan-Coronavirus Vaccines
New vaccines are being designed to help protect people from many different coronaviruses, including ones that could appear in the future.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11395077 on NIH RePORTER |
What this research studies
Researchers at several labs are designing vaccines that aim to teach your immune system to recognize many coronaviruses. They combine specially designed B-cell and T-cell targets and deliver them using harmless viral carriers like adenovirus and VSV to stimulate mucosal and whole-body immunity. These vaccine candidates will be tested in animals such as mice and hamsters to see if they prevent infection and disease, with data managed centrally and shared across the program. The overall goal is vaccines that could protect you against current and future coronaviruses that might emerge from animals.
Who could benefit from this research
Good fit: Ideal candidates for any future human trials would be adults at risk of coronavirus exposure or people willing to enroll in vaccine trials at participating centers.
Not a fit: This program is largely preclinical, so it may not provide direct, near-term benefit to people now, and those with known allergies to viral vaccine components may not be eligible for related trials.
Why it matters
Potential benefit: If successful, these vaccines could give people broader protection against multiple current and future coronaviruses, lowering the risk of infection and severe illness.
How similar studies have performed: Existing COVID-19 vaccines have protected against SARS-CoV-2, but broadly protective pan-coronavirus vaccines remain experimental and unproven in humans.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Diamond, Michael S — Washington University
- Study coordinator: Diamond, Michael S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.