Breast cancer risk genetics in Latin American women
Latin America Genomics of Breast Cancer Risk Study (LAGENO-BCR)
This project combines genetic and health data from tens of thousands of Latin American and Hispanic women to make breast cancer risk predictions more accurate for people with Latin American ancestry.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11400938 on NIH RePORTER |
What this research studies
You would be part of a project combining DNA and health information from about 28,500 women with breast cancer and 32,600 women without cancer across 11 Latin American countries and the U.S. Hispanic diaspora. Researchers will scan the genome to find genetic variants that raise or lower risk specifically in people with Indigenous American and mixed ancestries and will build polygenic risk scores that account for ancestry and geography. The consortium combines many existing studies to increase sample size and the statistical power to detect ancestry-specific risk markers. Results aim to make risk prediction tools more accurate and relevant for Latin American communities.
Who could benefit from this research
Good fit: Women of Latin American or Hispanic ancestry, both those with and without breast cancer, who can provide genetic samples or health information are ideal participants.
Not a fit: People who are not of Latin American or Hispanic ancestry or who do not share genetic or health data may not directly benefit from the project's tailored risk findings.
Why it matters
Potential benefit: Could produce more accurate, ancestry-specific risk tools that help tailor screening and prevention for Latin American women.
How similar studies have performed: Prior smaller studies in Hispanic/Latina women have found ancestry-specific variants that improved polygenic risk scores, but this larger consortium aims to confirm and extend those findings.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Fejerman, Laura — University of California at Davis
- Study coordinator: Fejerman, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.