Breast cancer genetics in Latin American women
Latin America Genomics of Breast Cancer Risk Study (LAGENO-BCR)
Researchers are pooling genetic and health information from thousands of Latina/Latin American women with and without breast cancer to make risk predictions more accurate for this group.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11400937 on NIH RePORTER |
What this research studies
This project combines genetic data from about 28,500 women with breast cancer and 32,600 women without cancer across 11 countries plus U.S. participants. Scientists will scan the genome to find variants linked to higher or lower breast cancer risk and will pay special attention to Indigenous American ancestry and regional differences. They will use those findings to improve polygenic risk scores and build prediction models that fit Latina/Latin American populations better. The goal is to create tools that could inform more personalized screening and prevention for women like me.
Who could benefit from this research
Good fit: Ideal candidates are Latina/Latin American women, with or without a breast cancer diagnosis, who can provide genetic samples and basic health information and who may have Indigenous American ancestry.
Not a fit: Women who are not of Latin American descent or who do not want genetic testing are less likely to see direct benefits from this project.
Why it matters
Potential benefit: If successful, this work could produce more accurate breast cancer risk scores for Latina/Latin American women, supporting earlier or more personalized screening and prevention.
How similar studies have performed: Previous, smaller genetic studies in Hispanic/Latina women have found ancestry-specific variants that improved risk predictions, and this larger consortium builds on that promising evidence.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Fejerman, Laura — University of California at Davis
- Study coordinator: Fejerman, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.