Breast cancer genetics in Latin American and Hispanic women
Latin America Genomics of Breast Cancer Risk Study (LAGENO-BCR)
This project analyzes DNA from thousands of Latin American and Hispanic women with and without breast cancer to improve risk prediction for people like them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11400939 on NIH RePORTER |
What this research studies
You would be part of a large effort that combines genetic and health data from about 28,500 women with breast cancer and 32,600 women without across 11 Latin American countries and U.S. Hispanic communities. Researchers will look across the genome to find genetic variants linked to higher or lower breast cancer risk and will factor in ancestry and geography. They will build and refine polygenic risk scores that aim to predict breast cancer risk more accurately for women with Latin American ancestry. The work brings together many existing studies so findings reflect the diversity of Latin American populations.
Who could benefit from this research
Good fit: Ideal participants are women of Latin American or Hispanic ancestry, with or without a breast cancer diagnosis, who can provide a DNA sample and basic health information.
Not a fit: People who are not of Latin American or Hispanic ancestry or who cannot provide genetic samples are less likely to see direct benefits from this project.
Why it matters
Potential benefit: If successful, this could lead to more accurate, ancestry-informed breast cancer risk estimates and better-targeted screening or prevention for Latin American and Hispanic women.
How similar studies have performed: Smaller prior studies in Hispanic/Latina women have already found ancestry-specific variants and shown that adding those variants can improve polygenic risk scores, but this consortium is much larger and broader.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Fejerman, Laura — University of California at Davis
- Study coordinator: Fejerman, Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.