BRCA Variants Knowledgebase for Cancer Genetics
Official title: The BRCA Exchange Knowledgebase for Clinical Cancer Genetics
Funded at University of California Santa Cruz · NIH-11396468 · Data updated 2026-11-12
A public online resource that collects and clarifies BRCA1/BRCA2 genetic variants to help doctors and patients understand cancer risk.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $645,954 |
| NIH project number | 5U24CA302705-02 |
| Project ID | NIH-11396468 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who have or are at risk for BRCA1/BRCA2-related cancers and who may benefit from clearer variant classifications.
✕Less likely to help
People without BRCA variants or without access to genetic testing may not benefit directly.
What this research studies
If you or a family member has or could have breast, ovarian, pancreatic, or prostate cancer linked to BRCA1 or BRCA2, this project builds a shared knowledgebase of BRCA variants. It aggregates data from major repositories and adds evidence on how variants affect cancer risk, aiming to make variant interpretations more consistent. The site will be useful for clinicians and patients seeking clear results to guide risk management and treatment decisions. The work is centered on improving how genetic information is classified and shared with the cancer genetics community.
Why it matters
Potential benefit: This could lead to more accurate genetic test results and better, personalized cancer risk and treatment planning.
How similar studies have gone: BRCA variant databases and ENIGMA panels have shown value in improving variant interpretation, with ongoing improvements as more data are shared.
Where this research is happening
-
University of California Santa Cruz
Santa Cruz, United States Active
Researchers
- Principal investigator: Cline, Melissa Suzanne — University of California Santa Cruz
- Study coordinator: Cline, Melissa Suzanne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.