Brain support-cell changes in alcohol dependence
Molecular Component - Contet
This project explores whether loss of a protein called GRM3 in brain support cells (astrocytes) disrupts brain circuits and promotes compulsive drinking in alcohol dependence.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11362011 on NIH RePORTER |
What this research studies
Researchers use mouse models that mimic repeated heavy drinking and withdrawal to study how long-term alcohol exposure alters the medial prefrontal cortex and its control over the amygdala. They will measure GRM3 levels in different cell types to determine whether reductions occur specifically in astrocytes versus neurons. The team will change GRM3 levels and observe effects on drinking behaviors and on communication between the infralimbic mPFC and the central amygdala. The aim is to connect these molecular and circuit changes to behaviors that drive alcohol dependence.
Who could benefit from this research
Good fit: People with alcohol dependence, a history of heavy drinking, or withdrawal symptoms would be most relevant to the goals of this research.
Not a fit: People without alcohol use problems or whose difficulties stem mainly from other substances may not receive direct benefit from this specific project.
Why it matters
Potential benefit: If successful, this work could point to a new brain-cell target for treatments that reduce heavy drinking and relapse.
How similar studies have performed: Prior animal studies have linked glutamate imbalance and mPFC–amygdala circuit disruption to alcohol dependence, and early data suggest GRM3 is a promising but relatively new target.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Contet, Candice — Scripps Research Institute, the
- Study coordinator: Contet, Candice
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.