Brain signals that control how the body uses energy
Dorsal raphe nucleus melanocortin signaling regulates energy homeostasis
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11137013
This project explores how specific brain cells help regulate eating and body weight.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11137013 on ClinicalTrials.gov |
What this research studies
Our brains have special areas that control how much we eat and how our bodies use energy. This project focuses on a specific brain region called the dorsal raphe nucleus and how certain cells there, called MC4R neurons, influence feeding. We are looking at how signals in these cells affect appetite and body weight in mice. Understanding these brain pathways could help us learn more about conditions related to eating and metabolism.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but could eventually inform future studies for individuals struggling with appetite regulation or weight management.
Not a fit: Patients seeking immediate treatment options for their condition would not directly benefit from this early-stage basic science.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how appetite is controlled, potentially opening new avenues for treating conditions like obesity or eating disorders.
How similar studies have performed: While some previous findings support the role of these brain cells in feeding, other recent studies have reported conflicting results, indicating an active and evolving area of investigation.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIANO, SABRINA — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: DIANO, SABRINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.