Brain-controlled hand movement using predicted muscle signals

Development of an EMG-controlled BCI for biomimetic control of hand movement in humans

NIH-funded research Northwestern University · NIH-11175307

Using brain signals to recreate natural finger movements and grip strength for people with high spinal cord injuries.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionNorthwestern University NIH-funded
Lab location1 site (Chicago, United States)
Project IDNIH-11175307 on NIH RePORTER

What this research studies

You would get tiny sensors placed over the part of the brain that controls movement (primary motor cortex) to record intent to move your hand. Researchers will translate those brain signals into predicted muscle commands (like EMG) rather than just finger positions. Those predicted muscle signals will drive a hand model to set finger positions, stiffness, and grip force so movements and grips feel more natural. The goal is to give people with high-level spinal cord injury clearer, force-aware control of their fingers than current brain interfaces provide.

Who could benefit from this research

Good fit: Adults with high-level spinal cord injury who have lost hand control and are medically eligible and willing to consider intracortical implants and device testing.

Not a fit: People who are unwilling or medically ineligible for brain implants, who do not have hand paralysis, or whose injury pattern does not match the trial criteria may not receive benefit.

Why it matters

Potential benefit: If successful, this approach could give people with high spinal cord injury more natural finger movement and direct control of grip force.

How similar studies have performed: Previous intracortical BCIs have restored cursor and some arm/finger movement but provided limited finger-by-finger and force control, making this EMG-prediction approach relatively novel though built on existing BCI progress.

Where this research is happening

Chicago, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.