Brain circuit patterns behind behavioral and mood symptoms in Alzheimer's
Assess Neural Circuits and Subtypes Underlying Dimensions of Neuropsychiatric Symptoms in Alzheimer's Disease
This project looks at brain circuit patterns and biological subtypes linked to behavioral and mood symptoms in people with mild cognitive impairment or Alzheimer's disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-11328568 on NIH RePORTER |
What this research studies
You may be asked to provide information about mood, behavior, and thinking while researchers collect brain imaging and other neurophysiological measures. The team will analyze symptom patterns across people from early to advanced Alzheimer's to find underlying brain-network signatures. They plan to group people into biological subtypes based on those circuit patterns and see if those subtypes track with clinical symptoms and how quickly the disease progresses. Your participation could help researchers match symptom patterns to specific brain changes.
Who could benefit from this research
Good fit: Ideal candidates are people with mild cognitive impairment or Alzheimer's disease who experience neuropsychiatric symptoms such as agitation, apathy, depression, psychosis, or related behavioral changes.
Not a fit: People without Alzheimer's disease or related cognitive impairment, or those without behavioral or mood symptoms, are unlikely to be relevant for this project.
Why it matters
Potential benefit: If successful, this work could help detect distinct behavioral symptom types earlier and guide more personalized monitoring or treatments.
How similar studies have performed: Previous research has linked brain networks to specific symptoms in Alzheimer's, but defining neurophysiological subtypes across disease stages is a newer and still-unproven approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Zhang, Yu — Stanford University
- Study coordinator: Zhang, Yu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.