Brain and behavior changes in teens and young adults with 22q11.2 deletion
2/2 - Neurodevelopmental Trajectories in 22q11.2 Deletion Syndrome in Adolescence and Young Adulthood
This project follows teens and young adults with 22q11.2 deletion to learn how their thinking, emotions, and health change over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11245711 on NIH RePORTER |
What this research studies
You would be followed over several years with regular visits to CHOP/Penn for interviews, thinking and memory tests, medical history reviews, and sometimes blood draws or brain scans. The team will also collect information about life experiences and medical problems to see how these factors relate to changes in mood, behavior, and cognition. Researchers will combine genetic information with health and environmental data to map different developmental paths toward ADHD, anxiety, autism, or psychosis-like symptoms. The aim is to find shared risk patterns that could help guide more personalized care in the future.
Who could benefit from this research
Good fit: Ideal candidates are adolescents and young adults with a confirmed 22q11.2 deletion (roughly ages 12–25), including those with or at risk for ADHD, anxiety, ASD, or psychosis-spectrum symptoms.
Not a fit: People without a 22q11.2 deletion, those unable to travel to the study site, or those seeking immediate symptom treatment may not receive direct benefit from participating.
Why it matters
Potential benefit: If successful, this work could help doctors spot early warning signs and tailor care for young people with 22q11.2 deletion.
How similar studies have performed: Prior research has linked 22q11.2 deletion to higher risk for ADHD, ASD, anxiety, and psychosis, but this focused, accelerated longitudinal approach during adolescence is relatively new.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Mcdonald-Mcginn, Donna Marie — Children's Hosp of Philadelphia
- Study coordinator: Mcdonald-Mcginn, Donna Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.