Botswana CASCADE: improving cervical cancer prevention for women living with HIV
Botswana CASCADE Clinical Trials Site
This project tries new ways to find and treat early cervical changes in women living with HIV in Botswana so fewer women die from cervical cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11103149 on NIH RePORTER |
What this research studies
You would be invited to join programs run from a new clinical site in Botswana that test ways to increase screening and treatment for cervical precancer. Methods include HPV self-sampling, offering screening outside traditional clinics and during antenatal visits, and using new technologies to better decide who needs treatment. The project will also work to make treatment easier to access, help more people complete therapy, and directly compare ablation methods for treating precancers. All approaches aim to prevent invasive cancer while avoiding unnecessary procedures and easing demands on local health services.
Who could benefit from this research
Good fit: Ideal candidates are women living with HIV in Botswana, including those attending antenatal care or those with a positive HPV screen or precancerous cervical lesions.
Not a fit: People who are not at risk for cervical HPV disease (for example men) or women who already have advanced invasive cervical cancer may not receive direct benefit from this program.
Why it matters
Potential benefit: If successful, this work could lower cervical cancer deaths by catching precancer earlier and improving treatment access and completion for women with HIV.
How similar studies have performed: HPV self-sampling and screen-and-treat approaches have reduced cervical cancer in other settings, but tailoring these strategies specifically for women living with HIV in southern Africa remains an area of active work.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Dryden-Peterson, Scott — Brigham and Women's Hospital
- Study coordinator: Dryden-Peterson, Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.