Boosting the immune system to stop smoldering myeloma from progressing
Improving immune modulation for smoldering myeloma
Testing whether treatments that reshape immune cells can help people with smoldering myeloma avoid developing active multiple myeloma.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11336294 on NIH RePORTER |
What this research studies
You would have blood and bone marrow samples checked to map the kinds and locations of immune cells in smoldering myeloma. Researchers will compare these immune features in people who do and do not progress to active myeloma. Some participants will receive the immune drug iberdomide alone or iberdomide plus another immune therapy so investigators can watch how immune cells change. The team wants to find immune patterns that predict progression and see if changing those cells can stop myeloma from developing.
Who could benefit from this research
Good fit: Adults diagnosed with smoldering myeloma (SMM), especially those not yet treated and at risk for progression, are the intended participants.
Not a fit: People who already have active/clinical multiple myeloma or unrelated health conditions are unlikely to benefit from this prevention-focused research.
Why it matters
Potential benefit: If successful, this work could delay or prevent smoldering myeloma from turning into active multiple myeloma.
How similar studies have performed: Previous randomized trials showed lenalidomide can reduce progression from smoldering to active myeloma, but applying iberdomide and detailed immune-cell mapping is a newer approach.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Dhodapkar, Madhav V — Fred Hutchinson Cancer Center
- Study coordinator: Dhodapkar, Madhav V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.