Boosting the immune response against canine osteosarcoma using activated dendritic cells
Generation of tumor specific immunity in canine osteosarcoma through dendritic cell hyperactivation
['FUNDING_U01'] · TUFTS UNIVERSITY BOSTON · NIH-10898910
This study is looking at ways to boost dogs' immune systems to better fight osteosarcoma by using special treatments that help important immune cells work harder, with the hope that what we learn can also help improve cancer treatments for both dogs and people.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10898910 on ClinicalTrials.gov |
What this research studies
This research investigates how to enhance the immune system's ability to fight osteosarcoma in dogs by hyperactivating dendritic cells, which are crucial for initiating immune responses. The approach involves using a combination of tumor lysate and specific adjuvants to stimulate these cells, promoting their migration to lymph nodes and improving the formation of memory T cells. By studying spontaneous canine osteosarcoma, the research aims to create a model that closely mimics human cancers, potentially leading to more effective treatments for both dogs and humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are dogs diagnosed with osteosarcoma who are eligible for immunotherapy treatments.
Not a fit: Dogs with other types of cancer or those not diagnosed with osteosarcoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved immunotherapy strategies for treating osteosarcoma in dogs, which may also inform similar approaches in human cancers.
How similar studies have performed: Previous research has shown promise in using dendritic cell activation to enhance anti-tumor immunity, suggesting that this approach may be effective.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LONDON, CHERYL A — TUFTS UNIVERSITY BOSTON
- Study coordinator: LONDON, CHERYL A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Animal Cancer Model