Boosting the body's defenses against advanced breast cancer by easing tumor pressure

Who could benefit from this research

What this research studies

For patients with advanced breast cancer, current immune treatments don't always work well, especially if immune cells can't get into the tumor. We've found that breast cancer tumors can be very dense, squeezing blood vessels and making it hard for helpful immune cells to reach the cancer. This project will use a medication called losartan, which is already used for high blood pressure, to see if it can loosen up the tumor tissue, open up blood vessels, and allow more immune cells to get inside. Our goal is to make existing immunotherapies more effective by helping the body's own defenses reach and attack the cancer.

Why it matters

Where this research is happening

• Boston University Medical Campus
  Boston, United States Active

Researchers

• Principal investigator: Jones, Dennis — Boston University Medical Campus
• Study coordinator: Jones, Dennis

Related research

Other NIH-funded projects on the same topics.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.