Boosting immunity to SARS-CoV-2 after bone marrow transplant using T cell therapy

Who could benefit from this research

What this research studies

For patients who have received a bone marrow transplant, their immune system is very weak, making them vulnerable to infections like SARS-CoV-2. This project is conducting a phase I clinical trial to see if giving patients donor-derived T cells, which are specialized immune cells, can safely improve their protection against SARS-CoV-2. Researchers are also working to create a new generation of these T cells that can better resist common medications used after transplant. The goal is to find new ways to keep transplant patients healthy and safe from severe infections.

Why it matters

Where this research is happening

• Children's Research Institute
  Washington, United States Active

Researchers

• Principal investigator: Conway, Susan — Children's Research Institute
• Study coordinator: Conway, Susan

Related research

Other NIH-funded projects on the same topics.

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• Understanding how kidney transplant patients respond to COVID-19 vaccination while on specific immunosuppressive therapy

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• Effects of T cell therapy on COVID-19 immunity after bone marrow transplant

  This study is looking at how a special treatment using immune cells from donors can help protect children who have had bone marrow transplants from getting COVID-19, and it aims to find safe ways to make these cells even more effective while they are on medications that weaken their immune system.

  NIH research Children's Research Institute · Washington, United States · NIH-10886377

• How COVID-19 infection and genes may influence memory and dementia risk

  This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11617103

• Targeting early oral GVHD to improve mouth health after stem cell transplant

  A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11616478

• Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury

  A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11594128

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.