Boosting immunity to SARS-CoV-2 after bone marrow transplant using T cell therapy
K23 Resubmission - Impact of adoptive T cell therapy on immunity to SARS-CoV-2 after bone marrow transplant
This project explores if special immune cells can help children and adults who have had a bone marrow transplant fight off SARS-CoV-2 infection.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11162427 on NIH RePORTER |
What this research studies
For patients who have received a bone marrow transplant, their immune system is very weak, making them vulnerable to infections like SARS-CoV-2. This project is conducting a phase I clinical trial to see if giving patients donor-derived T cells, which are specialized immune cells, can safely improve their protection against SARS-CoV-2. Researchers are also working to create a new generation of these T cells that can better resist common medications used after transplant. The goal is to find new ways to keep transplant patients healthy and safe from severe infections.
Who could benefit from this research
Good fit: This opportunity is for children and adults who have recently undergone a hematopoietic stem cell (bone marrow) transplant.
Not a fit: Patients who have not received a bone marrow transplant or are not at high risk for SARS-CoV-2 infection may not directly benefit from this specific approach.
Why it matters
Potential benefit: If successful, this approach could offer a new way to protect vulnerable bone marrow transplant patients from severe SARS-CoV-2 infections.
How similar studies have performed: Adoptive T cell therapies have shown promise in other viral infections and cancers, but this specific application for SARS-CoV-2 immunity in transplant patients is being newly explored in a clinical trial.
Where this research is happening
Washington, United States
- Children's Research Institute — Washington, United States (Active)
Researchers
- Principal investigator: Conway, Susan — Children's Research Institute
- Study coordinator: Conway, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.