Boosting heart metabolism to protect against diabetes-related heart issues
Increasing glycolysis in the diabetic heart is cardioprotective and improves glucose tolerance
This study is looking at whether boosting a process that helps the heart use sugar better can protect against heart problems caused by diabetes, and it's being tested in specially modified mice to see if it can lead to new treatments for people with diabetes-related heart issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-10915482 on NIH RePORTER |
What this research studies
This research investigates how increasing the rate of glycolysis in the heart can help protect against diabetic cardiomyopathy, a serious complication of diabetes. By focusing on a specific enzyme that regulates glycolysis, the study aims to restore the heart's ability to efficiently use glucose, which is often impaired in diabetic patients. The researchers are using genetically modified mice to explore whether enhancing cardiac glucose metabolism can improve heart function and overall glucose tolerance. If successful, this approach could lead to new treatments for individuals suffering from diabetes-related heart problems.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with type 1 or type 2 diabetes who are experiencing heart-related complications.
Not a fit: Patients without diabetes or those who do not have any cardiac issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve heart health and glucose management in diabetic patients.
How similar studies have performed: Previous research has shown promising results in enhancing cardiac metabolism, suggesting that this approach may be effective.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Humphries, Kenneth M — Oklahoma Medical Research Foundation
- Study coordinator: Humphries, Kenneth M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.