Boosting cells' cleanup system to help Alzheimer's
Pharmacologic Lysosomal Flux Activators to Ameliorate Alzheimer's Disease and Related Dementias
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11173603
New drugs are being developed to boost brain cells' waste‑clearing system for people with Alzheimer's and related dementias.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11173603 on ClinicalTrials.gov |
What this research studies
This work looks for medicines that help brain cells clear out harmful proteins, lipids, and damaged parts that build up in Alzheimer’s. Researchers screened hundreds of thousands of small molecules in cells to find compounds that speed the cell cleanup process called lysosomal flux without harming the immune system. Lab tests will identify how the best compounds work and which ones are safest and most promising. Successful leads would be pushed toward future testing in people and clinical trials.
Who could benefit from this research
Good fit: In future trials, people with early-stage Alzheimer's disease or related dementias would be the most likely candidates to try these new drugs.
Not a fit: People without Alzheimer's-related dementia or those in very advanced stages of the disease are less likely to benefit from these early-stage drug developments.
Why it matters
Potential benefit: If successful, these drugs could reduce toxic buildup in the brain and slow or lessen memory and thinking decline in people with Alzheimer's.
How similar studies have performed: Prior lab and animal studies show that boosting lysosomal clearance can lower disease markers, but safe non‑mTOR drugs that do this are still unproven in people.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KELLY, JEFFERY W — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: KELLY, JEFFERY W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia