Boosting cell membrane repair through caspase signaling
Official title: Membrane repair boosted by caspase signaling
Funded at Duke University · NIH-11014983 · Data updated 2026-11-12
This study looks at how a protein called caspase-7 helps intestinal cells delay their death so they can finish important jobs, and it hopes to find ways to improve cell repair and survival for people dealing with different health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | January 24, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $641,385 |
| NIH project number | 5R01AI181815-02 |
| Project ID | NIH-11014983 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve excessive cell death or impaired cell repair, particularly in the intestinal tract.
✕Less likely to help
Patients with stable conditions that do not involve cell death or repair issues may not benefit from this research.
What this research studies
This research investigates how certain proteins, known as caspases, help cells manage their death processes, particularly in the intestines. It focuses on the role of caspase-7 in delaying cell death to allow cells to complete necessary tasks before they die. By understanding these mechanisms, the research aims to enhance the repair of cell membranes, which is crucial for maintaining healthy tissue function. Patients may benefit from insights into how to improve cell survival and repair in various conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance cell survival and repair mechanisms in patients with conditions involving cell death.
How similar studies have gone: Previous research has shown promising results in understanding caspase functions, suggesting that this approach may lead to significant advancements in cell repair therapies.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Miao, Edward a — Duke University
- Study coordinator: Miao, Edward a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.