Bone's role in aging
Bone as a Target and a Regulator of Aging
['FUNDING_P01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11198006
This project looks at how bones influence aging and overall health, especially in older adults.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11198006 on ClinicalTrials.gov |
What this research studies
From a patient's point of view, researchers are studying bone not only as something that breaks down with age but as an active regulator of aging processes, using experiments in mice and analyses of human genetics. They are examining how bone's hormone-like (endocrine) functions change with age and how those changes affect blood formation, metabolism, and other body systems. The team combines lab experiments, mouse models, and human genetic data to trace links between bone mass and whole-body aging. Their goal is to find biological pathways that could be targeted to preserve bone and improve health during aging.
Who could benefit from this research
Good fit: Ideal candidates would be older adults with age-related bone loss or osteoporosis who might donate genetic samples or take part in related clinical studies.
Not a fit: People without bone or age-related health issues, or those needing immediate clinical treatment for acute injuries, may not see direct benefit from this basic research.
Why it matters
Potential benefit: If successful, this work could point to new ways to keep bones healthier and slow some age-related declines in overall health.
How similar studies have performed: Previous mouse studies and some human genetics work have shown that bone acts as an endocrine organ, but translating these findings into human therapies is still at an early stage.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARSENTY, GERARD — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: KARSENTY, GERARD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.