Bone strength and marrow fat in adults with long-standing type 1 diabetes
Bone Quality in Patients with Long-Standing Type 1 Diabetes
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11161483
Looks at bone structure and bone marrow fat to help explain why adults who've had type 1 diabetes for many years have a higher risk of fractures.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11161483 on ClinicalTrials.gov |
What this research studies
This project uses advanced imaging and lab information from adults with long-standing type 1 diabetes and matched controls to study bone quality. Researchers will examine bone density, bone microstructure at the hip using quantitative CT, and the amount and patterns of fat inside bone marrow. The work builds on an existing, well-characterized group of participants and their clinical and laboratory data. Findings will compare people with long-standing T1D to similar people without diabetes to find changes that may explain fracture risk.
Who could benefit from this research
Good fit: Middle-aged and older adults who have had type 1 diabetes for many years and who can attend the University of Colorado/participating study sites are ideal candidates.
Not a fit: Children, people without type 1 diabetes, or those with only recent-onset diabetes are unlikely to gain direct benefit from this specific work.
Why it matters
Potential benefit: Could help doctors identify new signs of weak bone in long-standing type 1 diabetes so fractures can be predicted and prevented earlier.
How similar studies have performed: Past studies have shown lower bone mineral density in type 1 diabetes but have not fully explained the high fracture risk, so using bone microstructure and marrow fat is a relatively new and promising approach.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARBALLIDO-GAMIO, JULIO — UNIVERSITY OF COLORADO DENVER
- Study coordinator: CARBALLIDO-GAMIO, JULIO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.