Bone matrix build-up and breakdown in living bones
Official title: Dynamics of Bone ECM Assembly and Resorption
Funded at University of Missouri Kansas City · NIH-11377382 · Data updated 2026-11-12
This grant studies how bone tissue forms its matrix and then resorbs it, using live cells and animals to understand osteoporosis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri Kansas City NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project start | July 18, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $463,743 |
| NIH project number | 5R01AR083438-03 |
| Project ID | NIH-11377382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with osteoporosis or bone fragility could benefit from future therapies informed by these mechanisms.
✕Less likely to help
Healthy individuals without bone disease or those not at risk may see limited direct benefit.
What this research studies
The project looks at how bone extracellular matrix forms and how osteoclasts break it down in real time, using advanced imaging in living systems. Researchers track collagen dynamics and cell behavior to reveal how osteoblasts become osteocytes and how bone resorption is regulated. The goal is to uncover mechanisms that could be targeted to keep bones strong in people at risk for osteoporosis. Findings could point toward new ways to prevent fragility fractures by balancing bone formation and loss.
Why it matters
Potential benefit: If successful, the work could lead to new strategies to prevent fractures in people with osteoporosis by improving bone strength.
How similar studies have gone: Previous imaging studies have shown dynamic ECM behavior and osteocyte differentiation in bone models, supporting the approach as promising.
Where this research is happening
-
University of Missouri Kansas City
Kansas City, United States Active
Researchers
- Principal investigator: Dallas, Sarah L — University of Missouri Kansas City
- Study coordinator: Dallas, Sarah L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.