Bone marrow's role in making inflammation-resolving molecules
Bone Marrow Functions of Novel Pro-Resolving Mediators
['FUNDING_OTHER'] · YALE UNIVERSITY · NIH-11166316
This work looks at how adult bone marrow cells produce natural molecules that calm inflammation and could help people with blood or immune conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11166316 on ClinicalTrials.gov |
What this research studies
I will be looking at hematopoietic stem and progenitor cells (HSPCs) in adult bone marrow to find which specialized pro-resolving mediators (SPMs) they make. Researchers will use advanced lipid profiling (metabololipidomics) and laboratory experiments under low-oxygen conditions that mimic the bone marrow to identify SPMs such as RvD1, RvD4, RvE1, MaR1, LXB4 and the newly found RvE4. The work combines analyses of human bone marrow samples with cellular and mechanistic studies to see how these molecules influence HSPC activation and white blood cell production. The aim is to reveal natural pathways the body uses to stop inflammation so those signals might inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates would be adults with blood or immune disorders or healthy adult bone marrow donors willing to provide samples at Yale or an affiliated site.
Not a fit: People with conditions unrelated to blood or immune function or those seeking an immediate clinical treatment are unlikely to receive direct benefit from this basic research.
Why it matters
Potential benefit: If successful, this could reveal ways to boost the body's own inflammation-resolving signals to improve recovery in blood diseases and infections.
How similar studies have performed: Previous studies have shown SPMs can speed resolution of inflammation and aid recovery in infection models, but applying these findings to human bone marrow HSPCs and the newly identified RvE4 is new.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIBREROS, STEPHANIA — YALE UNIVERSITY
- Study coordinator: LIBREROS, STEPHANIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Diseases