Bone marrow niches that control blood cell production
The microenvironment in bone marrow hematopoiesis
['FUNDING_OTHER'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11252795
This project looks at how different areas inside bone marrow help make healthy blood cells, which could help people with blood disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11252795 on ClinicalTrials.gov |
What this research studies
Researchers will use high-resolution imaging and laboratory experiments to map specific vascular niches inside the bone marrow and identify which zones guide the production of red blood cells and immune cells. They will examine how those microenvironments change during normal conditions, inflammation, or recovery after injury. Experiments will combine tissue imaging, cellular analyses, and molecular tests in model systems to reveal the signals that control blood cell formation. The team aims to define the anatomical cues that could be targeted to improve blood production in disease or after treatment.
Who could benefit from this research
Good fit: People with blood disorders such as anemia or low white blood cell counts, or those recovering blood counts after chemotherapy, would be most relevant to follow this work or be future participants.
Not a fit: Patients with conditions unrelated to blood production or those seeking immediate clinical treatment are unlikely to benefit directly from this basic laboratory-focused research.
Why it matters
Potential benefit: If successful, this work could point to new ways to boost blood cell recovery or treat anemia, neutropenia, and other blood disorders.
How similar studies have performed: Previous imaging and laboratory studies, including work from this group, have revealed marrow niche diversity, but turning those findings into clinical treatments is still at an early stage.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUCAS, DANIEL — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: LUCAS, DANIEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Blood Diseases