Bone cell interactions in Paget's disease
Osteoclast-Osteocyte Interaction's in Paget's Disease
This research looks at how bone cells act in people over 50 with Paget’s disease to find why focal bone lesions form and grow.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-11247511 on NIH RePORTER |
What this research studies
You or others with Paget’s disease may be asked to provide blood or bone samples so researchers can compare your osteoclasts and osteocytes with cells from people without the disease. The team will examine signaling molecules such as IL-6 and IGF1 in patient cells and use genetically modified mice that carry a measles virus protein in osteoclasts to recreate Paget-like bone lesions. They will also test what happens when IGF1 is specifically removed from osteoclasts to see if lesions still develop. The work combines lab studies on human cells, genetic mouse experiments, and patient sample analysis to pinpoint what drives the focal lesions and late-life onset of Paget’s disease.
Who could benefit from this research
Good fit: Adults over 50 with a clinical diagnosis of Paget’s disease who can provide blood or bone samples and medical history would be the best fit for participation.
Not a fit: People without Paget’s disease and those seeking immediate symptom relief should not expect direct benefit from taking part in this research.
Why it matters
Potential benefit: If successful, this work could point to ways to prevent or reduce new Paget lesions by targeting osteoclast signals like IGF1 or IL-6.
How similar studies have performed: Previous lab and mouse studies have reproduced Paget-like lesions by expressing measles nucleocapsid protein in osteoclasts and shown that osteoclast-derived IGF1 contributes to lesion formation, but translating these findings into treatments is still unproven.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Kurihara, Noriyoshi — Indiana University Indianapolis
- Study coordinator: Kurihara, Noriyoshi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.