Blood vessel lipids and how they shape artery health
Official title: Blood TG clearance and vascular biology
Funded at New York University D/b/a NYU Long Island School of Medicine · NIH-11327672 · Data updated 2026-11-12
Aimed at understanding how blood lipids move into artery walls and influence atherosclerosis, with a focus on endothelial cells and tiny lipid carriers.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University D/b/a NYU Long Island School of Medicine NIH-funded |
| Lab location | 1 site (Mineola, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $617,138 |
| NIH project number | 5P01HL160470-04 |
| Project ID | NIH-11327672 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with atherosclerotic cardiovascular disease or at risk due to high lipids may benefit from insights that lead to new therapies.
✕Less likely to help
This basic science study uses animal models and may not directly change care for patients in the short term.
What this research studies
This project looks at how lipoproteins cross the lining of blood vessels and how liver- and intestine-produced fats affect artery inflammation and plaque formation. Researchers will study what happens when specific genes involved in lipoprotein handling are turned off in mice to see how that changes endothelial cell behavior and lipid release. They will also examine how different lipoproteins impact tiny extracellular vesicles from endothelial cells and whether these vesicles promote inflammation or lipid buildup in macrophages. The findings could reveal new targets to slow or prevent plaque development in people with ASCVD.
Why it matters
Potential benefit: If successful, the work could identify new ways to reduce artery cholesterol buildup and inflammation, potentially slowing ASCVD progression.
How similar studies have gone: Prior work shows endothelial lipoprotein handling influences inflammation and atherogenesis; this project expands on those mechanisms in a targeted way.
Where this research is happening
-
New York University D/b/a NYU Long Island School of Medicine
Mineola, United States Active
Researchers
- Principal investigator: Goldberg, Ira J — New York University D/b/a NYU Long Island School of Medicine
- Study coordinator: Goldberg, Ira J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.