Blood vessel health in the body and brain during very early HIV and after starting treatment
Systemic and Central Nervous System Vasculopathy in Acute HIV and After Early Antiretroviral Therapy
This research looks at how blood vessels in the body and brain change during very early HIV infection and after people begin antiretroviral treatment, focusing on people who started treatment within about a month of infection.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11182669 on NIH RePORTER |
What this research studies
You would be part of a group of people who began HIV treatment very soon after infection and are followed over time. The project uses blood tests, vascular function measures, and brain imaging to track blood vessel health in the body and brain. Researchers compare these measures during acute infection and after early antiretroviral therapy to see how vascular changes evolve. The goal is to find patterns or markers that appear early and may predict later brain or blood-vessel problems.
Who could benefit from this research
Good fit: Ideal candidates are people diagnosed during acute HIV infection who started antiretroviral therapy within about 30 days of infection, especially those already enrolled in the SEARCH010/RV254 cohort.
Not a fit: People with long-standing (chronic) HIV who began treatment long after infection or people without HIV are unlikely to directly benefit from participation in this project.
Why it matters
Potential benefit: If successful, this work could reveal early markers of blood-vessel damage that help prevent stroke and cognitive decline in people with HIV.
How similar studies have performed: Past studies have shown blood-vessel problems in people with chronic HIV despite treatment, but applying these vascular and brain measures to people treated during acute infection is relatively new.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Holroyd, Kathryn — Columbia University Health Sciences
- Study coordinator: Holroyd, Kathryn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.