Blood protein signatures that reveal exercise-related heart failure risk
Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF Spectrum
This project looks at blood protein patterns during exercise to find early signs of a common form of heart failure called HFpEF in people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11352522 on NIH RePORTER |
What this research studies
You would give blood around an exercise test so researchers can measure thousands of proteins tied to how your body responds to exertion. The team will compare protein patterns from community volunteers, people known to have HFpEF, and clinical referral patients to find signatures that mark early disease. They are building on prior exercise testing and metabolite work in the Framingham Heart Study and adding detailed proteomic analyses. The goal is to link specific proteins to organ-level exercise reserve problems that could be used for screening or new treatments.
Who could benefit from this research
Good fit: Ideal candidates are adults at risk for HFpEF—often older adults with exercise intolerance, high blood pressure, obesity, or other cardiovascular risk factors—who can safely undergo an exercise test and blood draws.
Not a fit: People with other types of heart failure (reduced ejection fraction), unstable medical conditions, or those unable to perform exercise testing are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this could lead to blood tests that detect HFpEF earlier and point to new targets for prevention or therapy.
How similar studies have performed: Related work using exercise testing and metabolomics from the Framingham Heart Study showed promising links between exercise responses and HFpEF biology, while comprehensive proteomic profiling in this exercise context is a newer extension.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Nayor, Matthew G. — Boston University Medical Campus
- Study coordinator: Nayor, Matthew G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.