Blood protein markers for ALS and related disorders
Plasma Biomarkers for ALS & Related Disorders
['FUNDING_OTHER'] · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · NIH-11171888
Looking for proteins in blood that can help predict progression, track change over time, and match treatments for people with ALS and related motor neuron disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (CORAL GABLES, UNITED STATES) |
| Trial ID | NIH-11171888 on ClinicalTrials.gov |
What this research studies
Researchers will measure many proteins in blood samples from people with ALS, progressive muscular atrophy (PMA), and primary lateral sclerosis (PLS) and compare them to controls. They will collect samples over time to find markers that predict how fast symptoms will progress, that change with disease course, or that identify who might respond to specific therapies. The team will use sensitive proteomics and larger, longitudinal sample sets to overcome limits of past small, cross‑sectional studies. Successful markers would be usable in future clinical trials and could guide personalized treatment choices.
Who could benefit from this research
Good fit: Adults diagnosed with ALS or related motor neuron disorders (such as PMA or PLS) who can provide blood samples and attend follow‑up visits would be ideal candidates.
Not a fit: People without ALS/ALSRD or those unable to give blood samples or participate in longitudinal follow‑up are unlikely to gain direct benefit from this work.
Why it matters
Potential benefit: If successful, these blood markers could help predict disease course, monitor treatment effects, and select patients most likely to benefit from specific therapies.
How similar studies have performed: Previous blood proteomics in ALS have suggested candidate markers but were small, cross‑sectional, and not yet proven in clinical use, so this work builds on promising but unconfirmed findings.
Where this research is happening
CORAL GABLES, UNITED STATES
- UNIVERSITY OF MIAMI SCHOOL OF MEDICINE — CORAL GABLES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MCMILLAN, COREY T — UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
- Study coordinator: MCMILLAN, COREY T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amyotrophic Lateral Sclerosis Motor Neuron Disease