Blood protein and genetic patterns linked to heart problems and resilience in Black adults
Proteomic profiling to identify mechanisms of susceptibility and resilience to cardiac dysfunction in Black Americans
This project looks at blood proteins and genes in Black adults to find biological signs that lead to heart failure or help protect against it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11252286 on NIH RePORTER |
What this research studies
You'll be asked to provide a blood sample and health information so researchers can measure about 3,000 plasma proteins and analyze your DNA. They will link those biological data to heart tests, monitoring, and medical records to find patterns tied to heart failure and atrial fibrillation. Researchers will also compare these biological patterns with social factors like neighborhood and stress to see how they affect risk or resilience. The goal is to find molecules that explain why some Black adults develop heart problems while others stay healthy, which could guide new treatments.
Who could benefit from this research
Good fit: Black adults aged 21 or older who can provide blood samples and share health and social information, especially those with or at risk for heart disease or atrial fibrillation, are ideal candidates.
Not a fit: People who are not Black or who are unwilling to provide blood samples or share clinical and social information may not be eligible or directly benefit from this project.
Why it matters
Potential benefit: If successful, this work could identify blood-based markers and molecular targets that lead to earlier detection or new treatments for heart failure and atrial fibrillation in Black Americans.
How similar studies have performed: Previous proteomic and genomic studies have identified promising heart-disease biomarkers, but combining large-scale proteomics with social-determinant data in Black populations is a relatively new approach.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Shah, Amil M — Ut Southwestern Medical Center
- Study coordinator: Shah, Amil M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.