Blood pressure–guided fluid removal during hemodialysis
Official title: Using Intradialytic Blood Pressure Slopes to Guide Ultrafiltration in Hemodialysis Patients
Funded at VA North Texas Health Care System · NIH-11132726 · Data updated 2026-11-12
This project uses blood pressure patterns recorded during dialysis to guide how much fluid is removed for people on hemodialysis.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA North Texas Health Care System NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2020 |
| Project end | September 30, 2026 |
| Funding year | 2026 |
| NIH project number | 5I01CX002009-06 |
| Project ID | NIH-11132726 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults on maintenance hemodialysis—particularly Veterans—with suspected excess fluid or frequent intradialytic hypotension.
✕Less likely to help
People who are not on maintenance hemodialysis, who cannot have reliable blood pressure monitoring during dialysis, or who have conditions that prevent participation are unlikely to benefit from this project.
What this research studies
If you join, clinicians will continuously monitor your blood pressure during dialysis and use a computer algorithm that reads blood pressure slopes to suggest how much fluid to remove each session. The approach is designed to be patient-specific so fluid removal is tailored to your real‑time hemodynamics rather than fixed trial‑and‑error targets. The team aims to reduce episodes of dangerously low blood pressure during dialysis while also addressing long‑term excess fluid that raises heart and hospitalization risks. The work will be tested in Veterans on maintenance hemodialysis at participating VA sites.
Why it matters
Potential benefit: If successful, this method could reduce low blood pressure episodes during dialysis, lower fluid‑related heart complications, and decrease hospitalizations and deaths.
How similar studies have gone: Prior work shows bioimpedance and blood pressure monitoring can help identify fluid overload and reduce hypotension, but using continuous blood pressure slopes to drive a patient‑specific ultrafiltration algorithm in routine care is relatively new and not yet proven.
Where this research is happening
-
VA North Texas Health Care System
Dallas, United States Active
Researchers
- Principal investigator: Van Buren, Peter Noel — VA North Texas Health Care System
- Study coordinator: Van Buren, Peter Noel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.